Getting My ceesdekker To Work
Getting My ceesdekker To Work
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Human Rad51 filaments on double- and one-stranded DNA: correlating typical and irregular varieties with recombination function.
, Groningen scientists existing the effects of their efforts to create labs a lot more sustainable and provide techniques for other labs.
Our do the job was quickly followed up by others, most notably by Phaedon Avouris and colleagues at IBM, who in Oct 1998 printed their findings on transistors produced from single- and multi-walled carbon nanotubes in Applied Physics Letters.
2012, discovery that nucleoid occlusion underlies the accuracy of bacterial mobile division; and to start with ever review in the dynamics DNA supercoils and the invention of supercoil hopping
Experimental section diagram of negatively supercoiled DNA measured by magnetic tweezers and fluorescence,
All parameters were the identical for every panel With this online video, aside from the Original placement of the 6hb rod (shown in blue) around the nanopore. Simulations that terminated early on account of translocation on the rod in the pore are marked by a gray history.
2011, 1st in vitro measurements of transport across a single biomimetic nuclear pore complex; development of multiplexed magnetic tweezers for kilo-molecule experiments; and fixed the system of homology recognition in DNA homologous recombination
2003, shown the initial biosensors created out of a carbon nanotube; fixed the framework and mechanism of DNA restore proteins; and discovery of a brand new technique for fabricating good-condition nanopores for DNA translocation
one). The current–voltage curves confirmed substantial modulations with gate voltage, even at home temperature, which was per band bending in a ~0.6 eV bandgap semiconducting nanotube. These data also showed which the conductance might be modulated by 6 orders of magnitude by altering the gate voltage. The final results of this operate — a room-temperature transistor made out of a single carbon nanotube molecule — have been posted in Nature in May possibly 1998.
An built-in microfluidic System for quantifying drug permeation throughout biomimetic vesicle membranes
Many new phenomena ended up identified, and he and his research team set up a number one place During this discipline of research. Dekker and his exploration group learned new physics of nanotubes along with explored the feasibility of molecular electronics. In 1998, they were being the primary to build a transistor determined by a single nanotube molecule.
By way of example, we look at the nucleopore complex, a gateway concerning the cell nucleus and also the cytoplasm. This is a really intricate technique and thus difficult to analyze in the cell, so we use biomimetics. We reconstruct holes after which you can insert particular person factors of the nucleopore elaborate to review transportation by way of it at the single-molecule stage.’
Dekker heeft fundamentele ontdekkingen gedaan op het gebied van koolstof nanobuisjes. Mede vanwege deze werkzaamheden is hij al jaren de meest geciteerde fysicus in Nederland. Tegenwoordig onderzoekt hij achieved enkel-molecuultechnieken de biofysica van moleculen in de ceesdekker.net biologische cel. Dekker is naast zijn wetenschappelijk werk ook bekend vanwege zijn belangstelling voor de relatie tussen geloof en wetenschap en de discussie rond smart style and design in 2005. (nl)